Distinguishing Grade I Meningioma From Higher Grade Meningiomas Without Biopsy

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Distinguishing grade I meningioma from higher grade meningiomas without biopsy

BACKGROUND Many meningiomas are identified by imaging and followed, with an assumption that they are WHO Grade I tumors. The purpose of our investigation is to find clinical or imaging predictors of WHO Grade II/III tumors to distinguish them from Grade I meningiomas. METHODS Patients with a pathologic diagnosis of meningioma from 2002-2009 were included if they had pre-operative MRI studies ...

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Grade 2 meningioma and radiosurgery.

OBJECT World Health Organization Grade 2 meningiomas are aggressive tumors associated with a high recurrence rate leading to repeated surgical procedures, which can seriously worsen a patient's neurological status. Although radiosurgery is an increasingly popular technique, its role in the management of Grade 2 meningiomas has yet to be defined. In this study the authors aimed to evaluate radio...

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Late neurocognitive sequelae in patients with WHO grade I meningioma.

BACKGROUND Information on neurocognitive outcome following treatment of benign meningiomas is virtually lacking. This is remarkable considering that survival in these patients is the most favourable of all intracranial tumours. The aim of the present study was therefore to document the extent and nature of neurocognitive deficits in patients with World Health Organization (WHO) grade I meningio...

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Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas

Background Recent studies have reported mutations in the telomerase reverse transcriptase promoter (TERTp) in meningiomas. We sought to determine the frequency, clonality and clinical significance of telomere gene alterations in a cohort of patients with progressive/higher-grade meningiomas. Methods We characterized 64 temporally- and regionally-distinct specimens from 26 WHO grade III mening...

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Meningiomas with different histological grade in the same patient

RATIONALE Meningiomas are mostly regarded as benign tumors histologically,accounting for 13% to 26% of all primary intracranial tumors.It is testified that multiple meningiomas occur in <10% of cases.A case of concurrent grades I and II in the same patient in our hospital was described. PATIENT CONCERN A 66-year-old man who was experiencing headache and weakening in the left limbs, which grad...

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ژورنال

عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics

سال: 2015

ISSN: 0360-3016

DOI: 10.1016/j.ijrobp.2015.07.731